Discover novel pathways of gene regulation
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the activity of specific mRNA targets and play crucial roles in a wide variety of biological processes, including gene expression, development, proliferation, differentiation, and apoptosis. Implicated in human diseases, miRNA expression signatures are an emerging class of molecular biomarkers.
Agilent’s high-performance miRNA Microarray Platform, with its set of optimized reagents and hardware, enables comprehensive miRNA expression profiling across a broad dynamic range, allowing you to confidently elucidate the role that miRNAs play in your research. Exceptionally sensitive and selective oligonucleotide probes enable discrimination between closely related mature miRNAs. Agilent’s SurePrint technology and flexible probe design allow you to easily change and update content to accommodate newly discovered sequences. An efficient direct labeling procedure enables analysis of low total RNA sample input.
Significance analysis of microarray (SAM) plot showing differentially expressed miRNAs. Most miRNAs were not significant discriminators of class (gray circles), except for six miRNAs that were all significant and all upregulated in the class two tumors (white circles). miRNA, micro-RNA.1
1. Micro-RNAs associated with metastasis in uveal melanoma identified by multiplexed microarray profiling. Melanoma Research. 2008 18:184-190.