Agilent's portfolio of CGH (Comparative Genomic Hybridization), CGH+SNP (Comparative Genomic Hybridization plus Single Nucleotide Polymorphism), and CNV (Copy Number Variant) microarrays offers researchers access to a complete oligo array CGH solution for mapping large and small structural variations associated with developmental abnormalities, cancer development and progression, disease susceptibility, and differential drug responses.
- CGH microarrays allow for the highest quality copy number data. Our CGH microarrays are available for human, mouse, rat, and several model organisms, as well as in custom versions for more targeted analysis. They can be used to perform genome-wide analysis of insertions, deletions, and other structural variations.
- CGH+SNP microarrays extend our aCGH platform by including a set of single nucleotide polymorphism probes (SNPs) on the same microarray. This allows for the simultaneous, high-resolution detection of copy number and copy-neutral variations, including LOH and UPD, making these arrays ideal for cytogenetic research.
- CNV microarrays are designed to study the estimated 0.9-1.3% "normal" difference in copy number of the genomes of unrelated people. These arrays are best utilized in CNV association studies.
|Microarray type||Area of focus||LOH/UPD detection||Samples|
|CGH||~ 500 ISCA regions||No||Constitutional|
|CGH+SNP||Genes and exons||Yes||Constitutional/Cancer|
|CGH+SNP||~500 ISCA regions||Yes||Constitutional|
|CNV||Known CNVs||No||Association studies|
Hyb & Scanning